Description

6,7-Difluoro-2-Methylquinazolin-4(3H)-One is a high-value, fluorinated quinazolinone derivative serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in providing a versatile, functionalized scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential kinase inhibitors and other biologically active small molecule drug candidates.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and pesticides, leveraging the stability and bioactivity of the difluoroquinazolinone core.
• Material Science Precursor: Serves as a starting material for creating specialized fluorinated organic compounds used in electronic materials or liquid crystals.
• Chemical Biology Probe Development: Utilized in the design and synthesis of molecular probes for studying enzyme function and cellular pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring this precise fluorinated heterocycle.
• Academic & Institutional Research: Used in university and government laboratories for fundamental studies in heterocyclic and fluorine chemistry.

Basic Information

Product Name	6,7-Difluoro-2-Methylquinazolin-4(3H)-One
CAS No.	1033778-42-5
Molecular Formula	C9H6F2N2O
Molecular Weight	196.16 g/mol
Synonyms	6,7-Difluoro-2-methyl-3,4-dihydroquinazolin-4-one; 2-Methyl-6,7-difluoro-4(3H)-quinazolinone; 4(3H)-Quinazolinone, 6,7-difluoro-2-methyl-; 6,7-Difluoro-2-methyl-4-hydroxyquinazoline; 1033778-42-5; 6,7-Difluoro-2-methylquinazolin-4-ol; DFMQ
EINECS	Contact for details

Quality Control

Every batch of 6,7-Difluoro-2-Methylquinazolin-4(3H)-One is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay (HPLC), related substances, and residual solvents. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.