Description

Spiro[Piperidine-4,4'(1'H)-Quinolin]-2'(3'H)-One,Hydrochloride CAS NO 1032143-27-3 is a high-purity, complex heterocyclic compound featuring a spirocyclic core structure. This compound is of significant interest in advanced pharmaceutical research and development, particularly as a sophisticated building block or potential intermediate for novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of complex molecules targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of novel drug candidates, especially those with spirocyclic or fused quinoline-piperidine architectures.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to explore new chemical entities for various biological targets.
• Preclinical Development: Employed in the synthesis of compounds for pharmacokinetic, pharmacodynamic, and toxicology studies during early drug discovery phases.
• Chemical Biology Probes: Acts as a scaffold for developing specialized molecular probes to study enzyme function or receptor interactions in biological systems.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client-sponsored research programs.
• Academic Research: Utilized in university laboratories for methodological development in organic synthesis and investigations into new heterocyclic chemistry.

Basic Information

Product Name	Spiro[Piperidine-4,4'(1'H)-Quinolin]-2'(3'H)-One,Hydrochloride
CAS No.	1032143-27-3
Molecular Formula	C13H14N2O·HCl
Molecular Weight	250.73 g/mol
Synonyms	1'H-Spiro[piperidine-4,4'-quinoline]-2'(3'H)-one hydrochloride; 2',3'-Dihydro-1'H-spiro[piperidine-4,4'-quinoline]-2'-one hydrochloride; Spiro[piperidine-4,4'-quinoline]-2'(1'H)-one hydrochloride; 1032143-27-3; Spiro(piperidine-4,4'-quinoline)-2'-one hydrochloride; 1'H-Spiro(piperidine-4,4'-quinoline)-2'(3'H)-one HCl; Spirocyclic quinolinone piperidine hydrochloride
EINECS	Contact for details

Quality Control

Our Spiro[Piperidine-4,4'(1'H)-Quinolin]-2'(3'H)-One,Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure it meets the stringent requirements for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.