Description

Dichloro[1,3-Bis(2,4,6-Trimethylphenyl)-2-Imidazolidinylidene][(2-Isopropoxy)(5-Pentafluorobenzoylamino)Benzylidene]Ruthenium(II) is a highly specialized, second-generation Grubbs-Hoveyda type olefin metathesis catalyst. This compound matters for its exceptional thermal stability and functional group tolerance, enabling complex synthetic transformations under mild conditions. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Ring-Closing Metathesis (RCM): For the efficient synthesis of medium and large cyclic compounds, including macrocycles and heterocycles, crucial in drug discovery.
• Cross-Metathesis (CM): For the selective coupling of olefinic fragments in the production of fine chemicals and polymer precursors.
• Ring-Opening Metathesis Polymerization (ROMP): Used in the development of specialized polymers with unique mechanical and chemical properties for advanced materials.
• Pharmaceutical Intermediate Synthesis: Enabling key bond-forming steps in the scalable synthesis of active pharmaceutical ingredients (APIs).
• Agrochemical Research: Applied in the creation of novel bioactive molecules with potential herbicidal or insecticidal activity.
• Academic & Industrial R&D: A critical tool for methodology development and exploring new chemical space in organic synthesis.

Basic Information

Product Name	Dichloro[1,3-Bis(2,4,6-Trimethylphenyl)-2-Imidazolidinylidene][(2-Isopropoxy)(5-Pentafluorobenzoylamino)Benzylidene]Ruthenium(II)
CAS No.	1030618-02-0
Molecular Formula	C41H41Cl2F5N3ORu
Molecular Weight	877.77 g/mol
Synonyms	Grubbs-Hoveyda II Catalyst (Modified); Hoveyda-Grubbs Catalyst 2nd Generation (Amino-Substituted); [1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro[[2-(isopropoxy-κO)(5-[[(2,3,4,5,6-pentafluorophenyl)carbonyl]amino]phenyl)methylidene-κC]ruthenium; Dichloro(o-isopropoxyphenylmethylene)(1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene)ruthenium(II) with pentafluorobenzoylamino substituent; Amino-Substituted Hoveyda-Grubbs Catalyst; Ru Catalyst for Olefin Metathesis; CAS 1030618-02-0
EINECS	Contact for details

Quality Control

Every batch of our ruthenium metathesis catalysts undergoes rigorous analytical testing to ensure high catalytic activity and batch-to-batch consistency. Our quality protocols are designed to meet the stringent requirements of process chemistry and scale-up. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and performance-related specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a freezer. This product is light-sensitive and easily oxidized; prolonged exposure to air, moisture, or ambient temperature will lead to decomposition and loss of catalytic activity.

Specification

Item	Specification
Appearance	Dark green to brown crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in common organic solvents (DCM, toluene, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.