Description

Xphos Pd G1 is a highly active, second-generation palladium precatalyst featuring the XPhos ligand, designed for robust cross-coupling reactions. This compound matters because it offers superior stability, ease of handling, and consistent performance compared to many in-situ catalyst systems, directly addressing the need for reliable and reproducible synthesis in demanding applications. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require efficient and scalable catalytic transformations.

Application

• Pharmaceutical Intermediate Synthesis: Enabling key carbon-carbon and carbon-heteroatom bond formations (e.g., Buchwald-Hartwig amination, Suzuki-Miyaura coupling) in API development.
• Agrochemical Manufacturing: Catalyzing the synthesis of complex, bioactive molecules for crop protection agents.
• Material Science Research: Facilitating the polymerization and functionalization of organic electronic materials and polymers.
• Process Chemistry & Scale-up: Providing a reliable, pre-formed catalyst solution for robust and reproducible reaction conditions in kilo-lab and pilot plant operations.
• Academic & R&D Laboratories: Serving as a premier tool for methodological development in synthetic organic chemistry.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, flavors, and fragrances requiring precise catalytic steps.

Basic Information

Product Name	Xphos Pd G1
CAS No.	1028206-56-5
Molecular Formula	C₃₁H₄₃ClNPPd
Molecular Weight	610.50 g/mol
Synonyms	Chloro(2-dicyclohexylphosphino-2',4',6'-triisopropyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); Pd-PEPPSI-IPr; PEPPSI-IPr Palladium Catalyst; Palladium(II) 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene (3-chloropyridyl) complex; Second Generation XPhos Precatalyst; XPhos Pd G1 Precatalyst; Pd G1 XPhos; [PdCl(allyl)(XPhos)] (related precursor).
EINECS	Contact for details

Quality Control

Our Xphos Pd G1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high catalytic activity. Each lot undergoes comprehensive analytical testing, including NMR, HPLC, and elemental analysis, to verify identity, purity, and the absence of deleterious impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (argon or nitrogen) due to its moisture-sensitive and air-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Yellow to orange-brown crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Palladium (Pd) Content	16.5 - 18.0 %
Solubility	Soluble in common organic solvents (DCM, THF, toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.