Description

6,8-Methanoquinoline, 2-[(4R)-4,5-Dihydro-4-Phenyl-2-Oxazolyl]-5,6,7,8-Tetrahydro-7,7-Dimethyl-, (6R,8R)- is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound matters for its role as a critical chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs), where its specific stereochemistry is essential for biological activity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries working on novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of proprietary drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Asymmetric Catalysis Research: Used as a ligand precursor or a model substrate in the development of new asymmetric synthetic methodologies.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies and the generation of compound libraries for high-throughput screening.
• Process Chemistry Development: Employed in route scouting and optimization studies for the scalable, GMP-compliant manufacture of target molecules.
• Reference Standard: Provides a high-purity analytical standard for quality control and regulatory filing (e.g., FDA, EMA) of final drug substances.

Basic Information

Product Name	6,8-Methanoquinoline, 2-[(4R)-4,5-Dihydro-4-Phenyl-2-Oxazolyl]-5,6,7,8-Tetrahydro-7,7-Dimethyl-, (6R,8R)-
CAS No.	1027754-32-0
Molecular Formula	C23H26N2O
Molecular Weight	346.47 g/mol
Synonyms	(6R,8R)-2-[(4R)-4,5-Dihydro-4-phenyl-2-oxazolyl]-7,7-dimethyl-5,6,7,8-tetrahydro-6,8-methanoquinoline; (6R,8R)-2-[(4R)-4,5-Dihydro-4-phenyl-2-oxazolyl]-7,7-dimethyl-5,6,7,8-tetrahydroquinolino[8,7-b]bicyclo[3.2.1]octane; Chiral Methanoquinoline-Oxazoline Ligand; (6R,8R)-7,7-Dimethyl-2-[(4R)-4-phenyl-4,5-dihydro-1,3-oxazol-2-yl]-5,6,7,8-tetrahydroquinolino[8,7-b]bicyclo[3.2.1]octane; CAS 1027754-32-0
EINECS	Contact for details

Quality Control

Our 6,8-Methanoquinoline derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including chiral HPLC to confirm enantiomeric excess (ee) and standard identity/purity tests. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are provided and available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.