Description

(3,4-Dimethylphenyl)-Difluoroacetic Acid is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity imparted by the difluoroacetate group adjacent to a substituted phenyl ring, enabling precise molecular modifications. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly where the introduction of fluorine atoms is critical for enhancing metabolic stability, bioavailability, or binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors, CNS agents, and anti-inflammatory compounds.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and pesticides where fluorination improves lipophilicity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic materials, contributing to improved charge transport and thermal stability.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to introduce fluorine into polymer backbones, enhancing chemical resistance and surface properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, esterifications, and amide bond formations to construct complex, fluorinated molecular architectures.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D exploring new fluorination methodologies and structure-activity relationships (SAR).

Basic Information

Product Name	(3,4-Dimethylphenyl)-Difluoroacetic Acid
CAS No.	1027514-15-3
Molecular Formula	C10H10F2O2
Molecular Weight	200.18 g/mol
Synonyms	2,2-Difluoro-2-(3,4-dimethylphenyl)acetic Acid; α,α-Difluoro-3,4-dimethylbenzeneacetic Acid; 3,4-Dimethyl-α,α-difluorobenzeneacetic Acid; (3,4-Dimethylphenyl)difluoroethanoic Acid; Difluoro(3,4-dimethylphenyl)acetic Acid
EINECS	Contact for details

Quality Control

Our (3,4-Dimethylphenyl)-Difluoroacetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture, to ensure it meets the high standards required for research and scale-up applications. Certificates of Analysis (COA) documenting all critical parameters are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.