Description

2(3H)-Quinolinone, 4-Amino-3-[1,3-Dihydro-5-(4-Methyl-1-Piperazinyl)-2H-Benzimidazol-2-Ylidene]-5-Fluoro-, (3E)- is a sophisticated heterocyclic organic compound that serves as a key advanced intermediate in pharmaceutical research and development. Its complex molecular architecture, featuring fused quinolinone and benzimidazole rings with fluorine and piperazinyl substituents, makes it a valuable scaffold for creating novel bioactive molecules. This high-purity compound is primarily sought after by research institutions and pharmaceutical companies engaged in the discovery and synthesis of new therapeutic agents, particularly in oncology and targeted drug development.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, especially for targeted cancer therapies.
• Biochemical Research: Used as a reference standard and probe in studying enzyme inhibition and receptor-ligand interactions.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• API Development: Employed in the development and scale-up processes for new Active Pharmaceutical Ingredients (APIs).
• Chemical Biology: Utilized in the design and synthesis of chemical probes for cellular pathway analysis and target identification.

Basic Information

Item	Details
Product Name	2(3H)-Quinolinone, 4-Amino-3-[1,3-Dihydro-5-(4-Methyl-1-Piperazinyl)-2H-Benzimidazol-2-Ylidene]-5-Fluoro-, (3E)-
CAS No.	1027263-12-2
Molecular Formula	C21H22FN7O
Molecular Weight	407.45 g/mol
Synonyms	4-Amino-3-[1,3-dihydro-5-(4-methyl-1-piperazinyl)-2H-benzimidazol-2-ylidene]-5-fluoro-2(3H)-quinolinone; (3E)-4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2(3H)-ylidene]quinolin-2(1H)-one; 1027263-12-2; 4-Amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1H-benzimidazol-2(3H)-ylidene]-2(1H)-quinolinone; (3E)- isomer of the above compound.
EINECS	Contact for details

Quality Control

Our 2(3H)-Quinolinone, 4-Amino-3-[1,3-Dihydro-5-(4-Methyl-1-Piperazinyl)-2H-Benzimidazol-2-Ylidene]-5-Fluoro-, (3E)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity consistent with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment to support your critical R&D work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Solid powder
Color	Off-white to light yellow
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.