Description

2-Chloro-n-(Thiophen-2-Ylmethyl)Quinazolin-4-Amine is a high-purity, functionalized quinazoline derivative designed for advanced research and development. This compound serves as a critical pharmacological intermediate and scaffold in the synthesis of novel bioactive molecules. It is primarily utilized by pharmaceutical R&D teams and contract research organizations (CROs) focused on oncology, kinase inhibition, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of targeted kinase inhibitors and other small-molecule drug candidates.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization programs.
• Biochemical Probe Development: Serves as a starting material for creating tool compounds to study specific biological pathways and protein functions.
• Contract Manufacturing: Supplied to CDMOs for the cGMP or non-GMP production of active pharmaceutical ingredients (APIs) and advanced intermediates.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and chemical biology.

Basic Information

Item	Detail
Product Name	2-Chloro-n-(Thiophen-2-Ylmethyl)Quinazolin-4-Amine
CAS No.	1026287-65-9
Molecular Formula	C14H10ClN3S
Molecular Weight	287.77 g/mol
Synonyms	2-Chloro-N-[(thiophen-2-yl)methyl]quinazolin-4-amine; 4-Amino-2-chloro-N-(2-thienylmethyl)quinazoline; 2-Chloro-4-(thiophen-2-ylmethylamino)quinazoline; Quinazoline, 2-chloro-N-(2-thienylmethyl)-4-amino-; 1026287-65-9; 2-Chloro-N-(thiophen-2-ylmethyl)quinazolin-4-amine
EINECS	Contact for details

Quality Control

Our 2-Chloro-n-(Thiophen-2-Ylmethyl)Quinazolin-4-Amine is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.