Description

Nelonicline is a high-purity, non-nicotinic cholinergic agent with significant research and pharmaceutical potential. This compound matters as a selective modulator of neuronal nicotinic acetylcholine receptors, offering a valuable tool for neurological research and therapeutic development. It is needed by pharmaceutical R&D teams, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) focused on cognitive disorders and addiction treatment.

Application

• As a key intermediate in the synthesis of novel pharmaceutical compounds targeting the central nervous system.
• For neurological research as a reference standard in studies of nicotinic acetylcholine receptor function and modulation.
• In preclinical development of potential therapies for cognitive enhancement, neuropathic pain, and addiction.
• Utilized within academic and industrial laboratories for pharmacological assay development and screening.
• As a building block in medicinal chemistry for creating libraries of analogs with optimized selectivity and potency.

Basic Information

Product Name	Nelonicline
CAS No.	1026134-63-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	TC-5619; (E)-N-Methyl-4-[3-(5-isoxazolyl)phenyl]-3-buten-2-amine; TC5619; TC 5619; UNII-8F8Q22P81Q; 8F8Q22P81Q; CHEMBL2103876; BDBM50389345; AKOS009158974
EINECS	Contact for details

Quality Control

Our Nelonicline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling. Certificates of Analysis (COA) documenting full specifications are available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a dry environment and sealed immediately after use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.