Description

(E)-2-[(4-Methylphenyl)Sulfonyl]-3-[(2-Methyl-4-Quinolinyl)Amino]-2-Propenenitrile is a high-purity, advanced pharmaceutical intermediate characterized by its unique sulfonyl and quinolinyl functional groups. This compound is critical for enabling complex synthetic pathways in modern drug discovery and development. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel therapeutic agents, particularly in oncology and other specialized medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex small-molecule drug candidates, particularly those targeting kinase inhibition.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes for new chemical entities.
• Organic Synthesis Reagent: Serves as a versatile reagent for constructing complex heterocyclic frameworks in academic and industrial R&D laboratories.
• Biochemical Probe Development: Potential use in the development of probes for studying biological pathways and target validation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(E)-2-[(4-Methylphenyl)Sulfonyl]-3-[(2-Methyl-4-Quinolinyl)Amino]-2-Propenenitrile
CAS No.	1025568-34-6
Molecular Formula	C21H19N3O2S
Molecular Weight	377.46 g/mol
Synonyms	2-Propenenitrile, 2-[(4-methylphenyl)sulfonyl]-3-[(2-methyl-4-quinolinyl)amino]-, (2E)-; (E)-3-((2-Methylquinolin-4-yl)amino)-2-(p-tolylsulfonyl)acrylonitrile; (E)-2-(p-Tolylsulfonyl)-3-((2-methylquinolin-4-yl)amino)acrylonitrile; (E)-2-(4-Methylbenzenesulfonyl)-3-((2-methylquinolin-4-yl)amino)acrylonitrile; (E)-2-(Tosyl)-3-((2-methylquinolin-4-yl)amino)acrylonitrile; 1025568-34-6; CAS 1025568-34-6
EINECS	Contact for details

Quality Control

Our (E)-2-[(4-Methylphenyl)Sulfonyl]-3-[(2-Methyl-4-Quinolinyl)Amino]-2-Propenenitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.