Description

Spiro[2H-1-Benzopyran-2,4'-Piperidine]-1'-Carboxylic Acid, 3,4-Dihydro-4-Hydroxy-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate with a complex spirocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and receptor-targeted therapeutic research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for its role as a key building block in medicinal chemistry.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, especially in neurological and psychiatric disorder research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Process Chemistry Development: Serves as a key starting material (KSM) or advanced intermediate in the scale-up and optimization of API manufacturing processes.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target engagement.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.

Basic Information

Item	Details
Product Name	Spiro[2H-1-Benzopyran-2,4'-Piperidine]-1'-Carboxylic Acid, 3,4-Dihydro-4-Hydroxy-, 1,1-Dimethylethyl Ester
CAS No.	1024604-94-1
Molecular Formula	C19H25NO4
Molecular Weight	331.41 g/mol
Synonyms	tert-Butyl 4-hydroxy-3,4-dihydrospiro[chromene-2,4'-piperidine]-1'-carboxylate; 1'-Boc-4-hydroxy-3,4-dihydrospiro[chromene-2,4'-piperidine]; 4-Hydroxy-3,4-dihydrospiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester; 1,1-Dimethylethyl 3,4-dihydro-4-hydroxy-1'H-spiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylate; Spiro[chromene-2,4'-piperidine]-1'-carboxylic acid, 3,4-dihydro-4-hydroxy-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of Spiro[2H-1-Benzopyran-2,4'-Piperidine]-1'-Carboxylic Acid, 3,4-Dihydro-4-Hydroxy-, 1,1-Dimethylethyl Ester adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.