Description

(2R)-1,1,1-Trifluoro-2-Phenylpropan-2-Amine Hydrochloride is a high-purity chiral amine building block, specifically the hydrochloride salt of the (R)-enantiomer. This compound is a critical pharmaceutical intermediate valued for its trifluoromethyl group and defined stereochemistry, which are essential for modulating the biological activity and metabolic stability of drug candidates. It is primarily utilized by research organizations and pharmaceutical manufacturers engaged in the discovery and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disease research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, especially those targeting neurological receptors.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component in the research and process development of new APIs.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize lead compounds.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in stereoselective chemical reactions.
• Biochemical Research: Utilized as a reference standard or probe in studying enzyme interactions and metabolic pathways.
• Agrochemical Intermediate: Potential application in the synthesis of advanced, fluorinated crop protection agents.

Basic Information

Product Name	(2R)-1,1,1-Trifluoro-2-Phenylpropan-2-Amine Hydrochloride
CAS No.	1023329-97-6
Molecular Formula	C9H11ClF3N
Molecular Weight	225.64 g/mol
Synonyms	(R)-1,1,1-Trifluoro-2-phenylpropan-2-amine hydrochloride; (R)-α-Methyl-α-(trifluoromethyl)benzylamine hydrochloride; (R)-1-Phenyl-2-(trifluoromethyl)ethylamine hydrochloride; (2R)-1,1,1-Trifluoro-2-phenyl-2-propanamine hydrochloride; (R)-TFMPA HCl; (R)-Trifluoromethylphenylisopropylamine HCl; (R)-2-Amino-1,1,1-trifluoro-2-phenylpropane hydrochloride
EINECS	Contact for details

Quality Control

Our (2R)-1,1,1-Trifluoro-2-Phenylpropan-2-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chiral purity and chemical identity, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.