Description

11-(tert-Butyl)Spiro[1,2,3-Trihydroquinazoline-2,4'-Cyclohexane]-4-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic quinazoline structure. This compound is of significant value for research and development in medicinal chemistry, offering a sophisticated scaffold for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought by pharmaceutical R&D laboratories, agrochemical innovators, and specialty chemical manufacturers engaged in developing new therapeutic agents and high-value fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Agrochemical Development: Acts as a precursor in the research and synthesis of new generation pesticides and herbicides with potential novel modes of action.
• Organic Synthesis Reagent: Employed in advanced organic synthesis for constructing complex heterocyclic systems due to its reactive ketone and fused ring system.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development, quality control, and regulatory submissions.

Basic Information

Product Name	11-(tert-Butyl)Spiro[1,2,3-Trihydroquinazoline-2,4'-Cyclohexane]-4-One
CAS No.	1022600-91-4
Molecular Formula	C19H26N2O
Molecular Weight	298.43 g/mol
Synonyms	11-tert-Butylspiro[1,2,3-trihydroquinazoline-2,4'-cyclohexane]-4-one; 4H-Spiro[quinazoline-2,4'-cyclohexane]-4-one, 1,2,3,11-tetrahydro-11-(1,1-dimethylethyl)-; 11-(1,1-Dimethylethyl)-1,2,3,11-tetrahydro-4H-spiro[quinazoline-2,4'-cyclohexane]-4-one; 11-tert-Butyl-1,2,3,11-tetrahydrospiro[quinazoline-2,4'-cyclohexane]-4-one; CAS 1022600-91-4
EINECS	Contact for details

Quality Control

Our production of 11-(tert-Butyl)Spiro[1,2,3-Trihydroquinazoline-2,4'-Cyclohexane]-4-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.