Description

(3,3,4,4,4-D5)-(E/Z)-1-[4-(2-Chloroethoxy)Phenyl]-1-[4-(T-Butyldimethylsilyloxy)Phenyl]-2-Phenyl-1-Butene CAS NO 1020719-26-9 is a deuterated and silyl-protected stilbene derivative, a sophisticated advanced pharmaceutical intermediate (API) designed for cutting-edge research and development. Its value lies in its role as a key building block for synthesizing novel compounds where isotopic labeling and controlled functional group chemistry are critical. This high-purity chemical is primarily needed by pharmaceutical R&D laboratories and contract research organizations (CROs) working on targeted therapies and metabolic studies.

Application

• Deuterated Drug Discovery: As a deuterium-labeled intermediate for the synthesis of novel chemical entities (NCEs) where deuterium incorporation is used to modulate pharmacokinetics and metabolic stability.
• Metabolic Pathway Tracing: Serving as a labeled precursor in research to study drug metabolism and distribution using mass spectrometry and other analytical techniques.
• Selective Estrogen Receptor Modulator (SERM) Research: Acting as a key synthetic intermediate in the development of new SERM candidates due to its stilbene-based core structure.
• Chemical Biology Probes: Utilization in the creation of molecular probes for investigating biological targets and signaling pathways.
• Process Chemistry & Scale-Up: Use in route scouting and optimization for the commercial-scale production of complex active pharmaceutical ingredients (APIs).
• Academic Research: Employed in university and institutional labs for fundamental studies in organic synthesis, medicinal chemistry, and isotope chemistry.

Basic Information

Product Name	(3,3,4,4,4-D5)-(E/Z)-1-[4-(2-Chloroethoxy)Phenyl]-1-[4-(T-Butyldimethylsilyloxy)Phenyl]-2-Phenyl-1-Butene
CAS No.	1020719-26-9
Molecular Formula	C30H35D5ClO2Si
Molecular Weight	~503.2 g/mol (deuterated form)
Synonyms	1-[4-(2-Chloroethoxy)phenyl]-1-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-2-phenyl-1-butene-3,3,4,4,4-d5; Deuterated TBS-protected chlorotamoxifen derivative; (E/Z)-1-[4-(2-Chloroethoxy)phenyl]-1-[4-(tert-butyldimethylsilyloxy)phenyl]-2-phenyl-1-butene-d5; (3,3,4,4,4-Pentadeutero)-1-[4-(2-chloroethoxy)phenyl]-1-[4-[(tert-butyldimethylsilyl)oxy]phenyl]-2-phenyl-1-butene; Deuterated 4-Hydroxytamoxifen TBS ether derivative; D5-Labelled SERM Intermediate; CAS 1020719-26-9
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality control protocols to ensure batch-to-batch consistency and reliability for sensitive R&D applications. Our products undergo rigorous analytical testing, including HPLC for purity and NMR for structural and isotopic confirmation, to meet the exacting standards of pharmaceutical research. Certificates of Analysis (COA) detailing purity, isomeric ratio (E/Z), and deuterium enrichment are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound is light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Isomeric Ratio (E/Z) (HPLC)	Specified on COA
Deuterium Enrichment (NMR/MS)	≥ 95 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.