Description

4-(Pyrrolidin-1-Yl)-8-(Trifluoromethyl)Quinoline is a specialized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, combining a quinoline core with a pyrrolidine substituent and a trifluoromethyl group, which is highly valued for modulating the physicochemical properties of target molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Serves as a versatile building block for creating new active ingredients for crop protection, leveraging the biological activity often associated with the quinoline scaffold.
• Material Science Precursor: Used in the synthesis of advanced organic materials, including ligands for catalysis and components for organic electronics, where the electron-withdrawing trifluoromethyl group is beneficial.
• Chemical Biology Probe: Employed in academic and industrial research to develop molecular probes for studying biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for fine chemical manufacturers offering bespoke synthesis services to clients in life sciences.

Basic Information

Product Name	4-(Pyrrolidin-1-Yl)-8-(Trifluoromethyl)Quinoline
CAS No.	1020253-07-9
Molecular Formula	C14H13F3N2
Molecular Weight	266.26 g/mol
Synonyms	8-(Trifluoromethyl)-4-(1-pyrrolidinyl)quinoline; 4-(Pyrrolidin-1-yl)-8-(trifluoromethyl)quinoline; Quinoline, 4-(1-pyrrolidinyl)-8-(trifluoromethyl)-; 1020253-07-9; 4-Pyrrolidin-1-yl-8-trifluoromethylquinoline
EINECS	Contact for details

Quality Control

Our 4-(Pyrrolidin-1-Yl)-8-(Trifluoromethyl)Quinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to quality supports applications requiring high-purity intermediates for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.