Description

1-Ethynyl-2-(Methylsulfonyl)Benzene is a specialized aromatic compound featuring both an ethynyl and a methylsulfonyl functional group. This unique structure makes it a valuable high-purity building block for advanced organic synthesis and pharmaceutical research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and plant growth regulators, leveraging its reactive ethynyl group for structural diversification.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of advanced polymers, resins, and functional organic materials.
• Organic Synthesis Building Block: Employed in Sonogashira coupling and other palladium-catalyzed reactions to introduce acetylene functionalities into complex molecules.
• Ligand and Catalyst Development: Utilized for constructing sophisticated ligand frameworks in coordination chemistry and catalysis research.
• Life Sciences & Biochemical Probes: Acts as a core structure for developing fluorescent probes, biomarkers, and other tools for biochemical assays.

Basic Information

Item	Detail
Product Name	1-Ethynyl-2-(Methylsulfonyl)Benzene
CAS No.	1019928-25-6
Molecular Formula	C9H8O2S
Molecular Weight	180.22 g/mol
Synonyms	2-(Methylsulfonyl)phenylacetylene; (2-(Methylsulfonyl)phenyl)ethyne; 2-Ethynylphenyl methyl sulfone; 1-Ethynyl-2-(methylsulfonyl)benzene; Methyl 2-ethynylphenyl sulfone; 2-Acetylenylphenyl methyl sulfone
EINECS	Contact for details

Quality Control

We maintain a strict quality management system to ensure batch-to-batch consistency and high purity. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. Our manufacturing processes and quality controls are designed to meet the stringent requirements of cGMP and ISO 9001 standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.