Description

8-Chloro-5-(Trifluoromethyl)-1,2,3,4-Tetrahydroquinoline is a high-value, multi-functional heterocyclic building block characterized by its unique combination of a tetrahydroquinoline scaffold with chloro and trifluoromethyl substituents. This compound is essential for advanced research and development, particularly in the synthesis of novel, complex molecules where its structure imparts critical electronic and steric properties. It is primarily sought after by pharmaceutical, agrochemical, and advanced material scientists for creating targeted active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) agents, kinase inhibitors, and other biologically active molecules.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Material Science Research: Serves as a precursor for organic electronic materials, ligands for catalysis, and other specialty chemicals requiring a rigid, functionalized heterocyclic core.
• Chemical Biology & Proteomics: Employed as a scaffold for designing molecular probes, enzyme inhibitors, and tool compounds for biological pathway analysis.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	8-Chloro-5-(Trifluoromethyl)-1,2,3,4-Tetrahydroquinoline
CAS No.	1019356-62-7
Molecular Formula	C10H9ClF3N
Molecular Weight	235.63 g/mol
Synonyms	8-Chloro-5-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline; 1,2,3,4-Tetrahydro-8-chloro-5-(trifluoromethyl)quinoline; 5-(Trifluoromethyl)-8-chloro-1,2,3,4-tetrahydroquinoline; 8-Chloro-5-trifluoromethyl-1,2,3,4-tetrahydroquinoline; 1019356-62-7; 8-Chloro-5-(trifluoromethyl)tetrahydroquinoline
EINECS	Contact for details

Quality Control

Our 8-Chloro-5-(Trifluoromethyl)-1,2,3,4-Tetrahydroquinoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in GLP (Good Laboratory Practice) and cGMP (current Good Manufacturing Practice) environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.