Description

8-Bromo-2-chloroquinoline-3-carbaldehyde is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its unique halogenated quinoline scaffold makes it a critical intermediate for constructing complex molecules with tailored biological and material properties. This compound is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, antimicrobials, and anti-cancer agents.
• Agrochemical Research: Used to develop new generations of herbicides, fungicides, and pesticides by leveraging its reactive aldehyde and halogen sites for further functionalization.
• Material Science: Acts as a building block for creating organic semiconductors, liquid crystals, and photoactive materials due to the electron-deficient quinoline core.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and as a versatile substrate for introducing complexity into molecular libraries for high-throughput screening.
• Academic & R&D: A valuable reagent for methodological development in organic chemistry and for studying structure-activity relationships (SAR) in various applied research fields.

Basic Information

Item	Details
Product Name	8-Bromo-2-chloroquinoline-3-carbaldehyde
CAS No.	1018050-36-6
Molecular Formula	C10H5BrClNO
Molecular Weight	270.51 g/mol
Synonyms	2-Chloro-8-bromoquinoline-3-carboxaldehyde; 3-Formyl-8-bromo-2-chloroquinoline; 8-Bromo-2-chloro-3-quinolinecarboxaldehyde; 8-Bromo-2-chloroquinoline-3-carboxaldehyde; 1018050-36-6; 2-Chloro-8-bromoquinoline-3-carbaldehyde; 8-Bromo-2-chloro-quinoline-3-carbaldehyde
EINECS	Contact for details

Quality Control

Our 8-Bromo-2-chloroquinoline-3-carbaldehyde is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing all specifications is available for every batch upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.