Description

n-(Fluoro(Morpholino)Methylene)-n-Methylmethanaminium Hexafluorophosphate is a specialized fluorinated aminium salt primarily used as a high-performance coupling reagent in peptide synthesis. This compound matters for its superior reactivity and efficiency in forming amide bonds, a critical step in the production of complex peptides and active pharmaceutical ingredients (APIs). It is essential for research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-purity building blocks for advanced organic synthesis.

Application

• Peptide Synthesis: As a key coupling agent for the formation of amide bonds in solid-phase and solution-phase peptide synthesis.
• Pharmaceutical Intermediates: In the production of complex drug molecules and active pharmaceutical ingredients (APIs) requiring high-yield amidation steps.
• Bioconjugation: For linking peptides, proteins, or other biomolecules with labels, tags, or solid supports in diagnostic and therapeutic research.
• Organic Synthesis: As a versatile reagent for the synthesis of amides, esters, and other carboxylic acid derivatives in medicinal chemistry.
• High-Throughput Screening Libraries: Enabling the rapid and efficient construction of diverse compound libraries for drug discovery programs.
• Material Science: Potential use in the surface modification of polymers and the creation of advanced functional materials.

Basic Information

Product Name	n-(Fluoro(Morpholino)Methylene)-n-Methylmethanaminium Hexafluorophosphate
CAS No.	1017605-89-8
Molecular Formula	C8H15F7N2OP
Molecular Weight	319.18 g/mol
Synonyms	Fluoro-N,N,N',N'-tetramethylformamidinium Hexafluorophosphate (TFFH); TFFH Reagent; COMU-type Reagent Analog; Fluorodimethylamino-morpholinomethylene Hexafluorophosphate; (Fluoro(dimethylamino)methylene)dimethylammonium Hexafluorophosphate; N-[(Dimethylamino)(fluoro)methylene]-N-methylmethanaminium Hexafluorophosphate; Peptide Coupling Reagent TFFH
EINECS	Contact for details

Quality Control

Our n-(Fluoro(Morpholino)Methylene)-n-Methylmethanaminium Hexafluorophosphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance as a coupling reagent. Certificates of Analysis (COA) with full specification data are provided to guarantee compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.