Description

2-Chloro-8-Fluoroquinoline-3-Carbonitrile is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular scaffold, which serves as a versatile precursor for constructing complex pharmacophores and functional materials. This compound is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel quinolone-based antibiotics, kinase inhibitors, and other therapeutic agents.
• Agrochemical Research: Used in the synthesis of advanced fungicides, herbicides, and pesticides with enhanced activity profiles.
• Material Science Precursor: Serves as a building block for creating organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge-transport layers.
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes for studying biological targets and pathways.
• Catalyst Ligand Development: The quinoline core can be functionalized to create novel ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-Chloro-8-Fluoroquinoline-3-Carbonitrile
CAS No.	1017135-27-1
Molecular Formula	C10H4ClFN2
Molecular Weight	206.60 g/mol
Synonyms	2-Chloro-8-fluoroquinoline-3-carbonitrile; 8-Fluoro-2-chloroquinoline-3-carbonitrile; 3-Cyano-2-chloro-8-fluoroquinoline; Quinoline-3-carbonitrile, 2-chloro-8-fluoro-; 1017135-27-1
EINECS	Contact for details

Quality Control

Our 2-Chloro-8-Fluoroquinoline-3-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.