Description

Ethyl 4-Chloro-6,8-Dimethoxyquinoline-3-Carboxylate is a high-purity, multi-functional quinoline derivative serving as a critical advanced intermediate in modern organic synthesis. Its value lies in its versatile chemical structure, which provides a key scaffold for constructing complex molecules in pharmaceutical and agrochemical research. This compound is essential for R&D chemists and process development scientists working in medicinal chemistry, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially in the development of antimalarial, antibacterial, and anticancer agents.
• Agrochemical Research: Used as a precursor for developing novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the quinoline core.
• Material Science: Serves as a monomer or precursor for functional organic materials, including ligands for metal-organic frameworks (MOFs) and organic semiconductors.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies, heterocyclic chemistry exploration, and the development of new synthetic pathways.
• Fine Chemical Synthesis: Utilized for the custom synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	Ethyl 4-Chloro-6,8-Dimethoxyquinoline-3-Carboxylate
CAS No.	1016825-43-6
Molecular Formula	C₁₄H₁₄ClNO₄
Molecular Weight	295.72 g/mol
Synonyms	4-Chloro-6,8-dimethoxyquinoline-3-carboxylic acid ethyl ester; Ethyl 4-chloro-6,8-dimethoxy-3-quinolinecarboxylate; 3-Quinolinecarboxylic acid, 4-chloro-6,8-dimethoxy-, ethyl ester; 1016825-43-6; 4-Chloro-6,8-dimethoxy-quinoline-3-carboxylic acid ethyl ester; Ethyl 4-chloro-6,8-bis(methoxy)quinoline-3-carboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 4-Chloro-6,8-Dimethoxyquinoline-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.