Description

4-Chloro-6-Fluoro-8-Methylquinoline-3-Carbonitrile is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its unique molecular scaffold, featuring halogen and nitrile substituents, makes it a versatile intermediate for constructing complex pharmacophores. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly for developing new quinoline-based antimicrobials, kinase inhibitors, and anticancer agents.
• Agrochemical Research: Serves as a core structure for developing new generations of herbicides, fungicides, and pesticides with enhanced efficacy and selectivity.
• Material Science: Used in the research of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient quinoline core.
• Chemical Synthesis: Acts as a versatile building block for further functionalization via reactions at the chloro, fluoro, nitrile, or quinoline ring positions.
• Ligand & Catalyst Development: Employed in the design of novel chelating ligands and organocatalysts for asymmetric synthesis and metal-catalyzed cross-coupling reactions.

Basic Information

Product Name	4-Chloro-6-Fluoro-8-Methylquinoline-3-Carbonitrile
CAS No.	1016773-98-0
Molecular Formula	C₁₁H₆ClFN₂
Molecular Weight	220.63 g/mol
Synonyms	4-Chloro-6-fluoro-8-methylquinoline-3-carbonitrile; 3-Cyano-4-chloro-6-fluoro-8-methylquinoline; 8-Methyl-4-chloro-6-fluoroquinoline-3-carbonitrile; 1016773-98-0; 4-Chloro-6-fluoro-8-methyl-3-quinolinecarbonitrile; 6-Fluoro-8-methyl-4-chloroquinoline-3-carbonitrile
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-Fluoro-8-Methylquinoline-3-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Custom synthesis and purity grades (e.g., >97%, >98%, >99%) are available to meet specific research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.