Description

4-Chloro-8-(Difluoromethoxy)Quinoline-3-Carbonitrile is a high-value, multi-functional quinoline derivative that serves as a critical synthetic intermediate. Its molecular architecture, featuring chloro, difluoromethoxy, and nitrile functional groups, makes it a versatile building block for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly for antiviral, antibacterial, and anticancer research.
• Agrochemical Synthesis: Building block for developing new-generation pesticides, herbicides, and fungicides, leveraging the bioactivity of the quinoline core.
• Material Science Research: Used in the development of organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient quinoline structure.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the design and synthesis of fluorescent probes or molecular tags for biological imaging and diagnostic applications.

Basic Information

Product Name	4-Chloro-8-(Difluoromethoxy)Quinoline-3-Carbonitrile
CAS No.	1016769-41-7
Molecular Formula	C11H5ClF2N2O
Molecular Weight	254.62 g/mol
Synonyms	4-Chloro-8-(difluoromethoxy)quinoline-3-carbonitrile; 8-(Difluoromethoxy)-4-chloroquinoline-3-carbonitrile; 3-Cyano-4-chloro-8-(difluoromethoxy)quinoline; Quinoline-3-carbonitrile, 4-chloro-8-(difluoromethoxy)-; 1016769-41-7
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-8-(Difluoromethoxy)Quinoline-3-Carbonitrile is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.