Description

1-(4-Bromo-2-Fluorophenyl)-5-Oxopyrrolidine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its halogenated aromatic and pyrrolidinone structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and anti-inflammatory therapeutics. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and process chemistry, where consistent quality and reliable supply are paramount.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those targeting neurological disorders.
• Organic Synthesis Research: Used in academic and industrial R&D for constructing novel heterocyclic compounds and exploring structure-activity relationships (SAR).
• Preclinical Development: Serves as a critical starting material for producing compounds for pharmacological screening and toxicology studies.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial manufacturing of new chemical entities (NCEs).
• Agrochemical Research: Potential intermediate in the development of new crop protection agents with specific biological activity.
• Material Science: Investigated as a monomer or precursor for specialty polymers with unique thermal or optical properties.

Basic Information

Product Name	1-(4-Bromo-2-Fluorophenyl)-5-Oxopyrrolidine-3-Carboxylic Acid
CAS No.	1016697-56-5
Molecular Formula	C11H9BrFNO3
Molecular Weight	302.10 g/mol
Synonyms	5-Oxo-1-(4-bromo-2-fluorophenyl)pyrrolidine-3-carboxylic acid; 1-(4-Bromo-2-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid; 4-Bromo-2-fluoro-1-(5-oxo-3-pyrrolidinecarbonyl)benzene; 3-Carboxy-1-(4-bromo-2-fluorophenyl)-2-pyrrolidinone; 1-(4-Bromo-2-fluorophenyl)-2-oxopyrrolidine-4-carboxylic acid (tautomer); 1016697-56-5; BFPOCA (abbreviation)
EINECS	Contact for details

Quality Control

Our production of 1-(4-Bromo-2-Fluorophenyl)-5-Oxopyrrolidine-3-Carboxylic Acid adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and current industry standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.