Description

3-Quinolinecarboxylic Acid, 7-(4-Acetyl-1-Piperazinyl)-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-, (3-Chlorophenyl)Methyl Ester is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, particularly in the creation of novel antibacterial agents targeting DNA gyrase and topoisomerase IV. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions focused on developing next-generation fluoroquinolone antibiotics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel fluoroquinolone antibiotic candidates.
• Antibacterial Drug R&D: Used in research programs targeting Gram-positive and Gram-negative bacterial infections.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and safety profiles.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes for API manufacturing.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical analysis.
• Biochemical Research: Tool compound for studying bacterial enzyme inhibition mechanisms.

Basic Information

Item	Detail
Product Name	3-Quinolinecarboxylic Acid, 7-(4-Acetyl-1-Piperazinyl)-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-, (3-Chlorophenyl)Methyl Ester
CAS No.	1016492-22-0
Molecular Formula	C26H25ClFN3O4
Molecular Weight	497.95 g/mol
Synonyms	7-(4-Acetylpiperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (3-chlorophenyl)methyl ester; (3-Chlorobenzyl) 7-(4-acetyl-1-piperazinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate; GSK-2140944 Intermediate; Gepotidacin Intermediate; Benzyl Ester Derivative of Novel Topoisomerase Inhibitor
EINECS	Contact for details

Quality Control

Every batch of our 3-Quinolinecarboxylic Acid, 7-(4-Acetyl-1-Piperazinyl)-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-, (3-Chlorophenyl)Methyl Ester is manufactured under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.