Description

3-{4,8-Dimethyl-7-[(2-Methylprop-2-En-1-Yl)Oxy]-2-Oxo-2H-Chromen-3-Yl}-n-(4-Sulfamoylbenzyl)Propanamide is a high-purity, advanced pharmaceutical intermediate with a complex coumarin-based structure. This compound is critical for the research and development of novel therapeutic agents, particularly in targeted drug discovery programs. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in synthesizing potent, small-molecule inhibitors and other bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially protease inhibitors and kinase inhibitors.
• Biochemical Research: Used as a reference standard or active probe in enzymatic and cellular assay development for target validation studies.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) optimization in lead compound development.
• Preclinical Development: Employed in the production of compounds for pharmacokinetic, pharmacodynamic, and toxicology studies.
• Academic Research: Utilized in university and institutional labs for investigating coumarin derivative pharmacology and chemical biology.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	3-{4,8-Dimethyl-7-[(2-Methylprop-2-En-1-Yl)Oxy]-2-Oxo-2H-Chromen-3-Yl}-n-(4-Sulfamoylbenzyl)Propanamide
CAS No.	1010877-07-2
Molecular Formula	C25H28N2O6S
Molecular Weight	484.57 g/mol
Synonyms	3-(4,8-Dimethyl-7-((2-methylallyl)oxy)-2-oxo-2H-chromen-3-yl)-N-((4-sulfamoylphenyl)methyl)propanamide; 3-(4,8-Dimethyl-7-((2-methylprop-2-en-1-yl)oxy)-2-oxo-2H-chromen-3-yl)-N-((4-sulfamoylphenyl)methyl)propanamide; Propanamide, 3-[4,8-dimethyl-7-[(2-methyl-2-propen-1-yl)oxy]-2-oxo-2H-1-benzopyran-3-yl]-N-[[4-(aminosulfonyl)phenyl]methyl]-; CAS 1010877-07-2
EINECS	Contact for details

Quality Control

Every batch of this pharmaceutical intermediate is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, supporting our clients' regulatory filings. Certificates of Analysis (COA) detailing HPLC purity, related substances, and residual solvents are available for each lot. Our quality standards align with ICH guidelines, and we can support development under cGMP conditions for advanced phase projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider inert atmosphere packaging to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.