Description

n-[(11Br)-2,6-Bis[3,5-Bis(trifluoromethyl)phenyl]-4-oxidodinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl]-1,1,1-trifluoro-methanesulfonamide is a sophisticated organophosphorus compound featuring a unique dinaphthodioxaphosphepin core structure, heavily substituted with electron-withdrawing trifluoromethyl groups. This compound is of significant interest for its potential role as a highly specialized ligand or catalyst precursor in advanced synthetic chemistry, particularly in facilitating challenging cross-coupling and asymmetric transformations. It is primarily targeted at research and development laboratories in the pharmaceutical and advanced materials sectors, where its distinct electronic and steric properties can unlock novel synthetic pathways.

Application

• Catalyst Ligand in Cross-Coupling Reactions: Acts as a specialized ligand for transition metals (e.g., Pd, Ni) in Buchwald-Hartwig amination, Suzuki-Miyaura, and other C-C/C-N bond-forming reactions.
• Precursor for Asymmetric Catalysis: Serves as a key building block for developing chiral phosphine-based catalysts used in the synthesis of enantiomerically pure pharmaceutical intermediates.
• Material Science Research: Investigated for incorporation into novel organic electronic materials or as a modifying agent for surfaces due to its bulky, fluorinated structure.
• Pharmaceutical R&D: Utilized in the discovery and process development stages for creating complex, fluorinated active pharmaceutical ingredients (APIs).
• Academic & Industrial Research: A valuable tool for chemists exploring new methodologies in organometallic and fluorine chemistry.

Basic Information

Item	Details
Product Name	n-[(11Br)-2,6-Bis[3,5-Bis(trifluoromethyl)phenyl]-4-oxidodinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl]-1,1,1-trifluoro-methanesulfonamide
CAS No.	1010800-02-8
Molecular Formula	C41H17BrF15NO5PS
Molecular Weight	1040.51 g/mol
Synonyms	1,1,1-Trifluoro-N-[(11-bromo-2,6-bis[3,5-bis(trifluoromethyl)phenyl]-4-oxido-4H-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl)]methanesulfonamide; Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin, methanesulfonamide derivative; Bromo-substituted trifluoromethanesulfonamide phosphine oxide; Specialty phosphine sulfonamide ligand; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced chemical intermediate adheres to stringent quality assurance protocols. Every batch is characterized using advanced analytical techniques including NMR (1H, 13C, 19F, 31P), HPLC, and mass spectrometry to ensure structural integrity and high purity levels suitable for research and catalytic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your R&D and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment and handled under an inert atmosphere (e.g., nitrogen or argon) for long-term stability and to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.