Description

o-(2,2-Difluoroethyl)Hydroxylamine Hydrochloride is a specialized organic building block featuring a difluoroethyl group linked to a hydroxylamine hydrochloride moiety. This compound is valued for its role as a key intermediate in the synthesis of complex molecules, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought by research and development chemists, process development teams, and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for constructing molecules with specific fluorine-containing pharmacophores.

Application

• Pharmaceutical Intermediate: A critical synthon for the research and production of fluorinated drug candidates, potentially targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the difluoroethyl group can enhance biological activity and metabolic stability.
• Chemical Biology & Proteomics: Serves as a reagent for the selective modification of proteins or other biomolecules, useful in probe development and activity-based protein profiling (ABPP).
• Material Science Research: Employed in the synthesis of fluorinated polymers or specialty chemicals with unique surface properties or stability.
• Cross-Coupling Reactions: Acts as a precursor for palladium-catalyzed reactions, such as Buchwald-Hartwig amination, to introduce nitrogen-containing difluoroethyl fragments.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and commercial-scale manufacturing of target molecules in regulated industries.

Basic Information

Product Name	o-(2,2-Difluoroethyl)Hydroxylamine Hydrochloride
CAS No.	1010097-82-1
Molecular Formula	C2H6ClF2NO
Molecular Weight	145.52 g/mol
Synonyms	O-(2,2-Difluoroethyl)hydroxylamine hydrochloride; 2,2-Difluoroethoxylamine hydrochloride; N-(2,2-Difluoroethoxy)amine hydrochloride; Hydroxylamine, O-(2,2-difluoroethyl)-, hydrochloride; (2,2-Difluoroethoxy)amine hydrochloride; 1010097-82-1; O-(2,2-Difluoroethyl)hydroxyammonium chloride
EINECS	Contact for details

Quality Control

Our o-(2,2-Difluoroethyl)Hydroxylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for advanced chemical intermediates. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, impurity profile, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent oxidation and moisture uptake. Keep away from strong acids, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.