Description

5-tert-Butoxyquinazoline-2,4-Diamine is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1009734-33-1. This compound is valued for its role as a critical building block in the synthesis of complex, biologically active molecules, particularly kinase inhibitors. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, especially in the fields of oncology and targeted drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of tyrosine kinase inhibitors and other targeted cancer therapies.
• Organic Synthesis Building Block: Used in medicinal chemistry for constructing complex quinazoline-based scaffolds for biological screening.
• Research & Development: Essential for academic and industrial R&D labs exploring new chemical entities (NCEs) with potential pharmacological activity.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Biochemical Research: Serves as a tool compound for studying enzyme inhibition mechanisms and structure-activity relationships (SAR).

Basic Information

Product Name	5-tert-Butoxyquinazoline-2,4-Diamine
CAS No.	1009734-33-1
Molecular Formula	C₁₂H₁₈N₄O
Molecular Weight	234.30 g/mol
Synonyms	2,4-Diamino-5-tert-butoxyquinazoline; 5-(tert-Butoxy)quinazoline-2,4-diamine; Quinazoline-2,4-diamine, 5-(1,1-dimethylethoxy)-; 5-tert-Butyloxyquinazoline-2,4-diamine; 5-(tert-Butoxy)-2,4-quinazolinediamine
EINECS	Contact for details

Quality Control

Our 5-tert-Butoxyquinazoline-2,4-Diamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.