Description

7-Fluoro-6-Nitroquinazoline-2,4(1H,3H)-Dione is a high-purity, advanced pharmaceutical intermediate characterized by its distinct fluorinated and nitrated quinazoline-dione structure. This compound is of significant commercial importance for its role as a critical building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel oncology and anti-inflammatory treatments. The precise molecular architecture of this intermediate enables the fine-tuning of drug potency and selectivity.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of small molecule kinase inhibitors for targeted cancer therapies.
• Oncology Drug Discovery: Used in research and development programs focused on creating novel compounds that interfere with specific signaling pathways in cancer cells.
• Biochemical Research: Serves as a standard or reference compound in enzymatic assays and structure-activity relationship (SAR) studies.
• API Synthesis: Employed in the controlled synthesis of Active Pharmaceutical Ingredients (APIs) for preclinical and clinical trial material.
• Chemical Library Building: Utilized for the generation of diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	7-Fluoro-6-Nitroquinazoline-2,4(1H,3H)-Dione
CAS No.	1007308-74-8
Molecular Formula	C8H4FN3O4
Molecular Weight	225.14 g/mol
Synonyms	7-Fluoro-6-nitro-1H,3H-quinazoline-2,4-dione; 6-Nitro-7-fluoroquinazoline-2,4(1H,3H)-dione; 1H-Quinazoline-2,4-dione, 7-fluoro-6-nitro-; 7-Fluoro-6-nitro-2,4-dihydroxyquinazoline; 7-Fluoro-6-nitroquinazoline-2,4-diol; 1007308-74-8; Fluoronitroquinazolinedione
EINECS	Contact for details

Quality Control

Our 7-Fluoro-6-Nitroquinazoline-2,4(1H,3H)-Dione is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.