Description

2-{1-[5-Cyclopropyl-3-(Trifluoromethyl)-1H-Pyrazol-1-Yl]Propan-2-Yl}-4-Methyl-1,3-Thiazole-5-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure incorporating pyrazole and thiazole moieties. This compound is of significant commercial value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily sought by research institutions and manufacturers in the global pharmaceutical, agrochemical, and specialty chemical industries engaged in drug discovery and development programs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, inflammatory diseases, and metabolic conditions.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where its trifluoromethyl and cyclopropyl groups can contribute to enhanced biological activity and environmental stability.
• Chemical Biology Probe: Employed in academic and industrial research to create molecular probes for studying enzyme function and protein-ligand interactions due to its distinctive structural features.
• Material Science Applications: Potential use in the synthesis of specialty polymers or ligands for catalysts, leveraging its carboxylic acid functionality for further derivatization.
• Contract Research & Development (CRO/CMO): Supplied to contract research organizations and custom synthesis manufacturers for client-specific projects requiring complex heterocyclic chemistry.

Basic Information

Product Name	2-{1-[5-Cyclopropyl-3-(Trifluoromethyl)-1H-Pyrazol-1-Yl]Propan-2-Yl}-4-Methyl-1,3-Thiazole-5-Carboxylic Acid
CAS No.	1006682-82-1
Molecular Formula	C15H16F3N3O2S
Molecular Weight	359.37 g/mol
Synonyms	4-Methyl-2-[2-[5-cyclopropyl-3-(trifluoromethyl)pyrazol-1-yl]propyl]-1,3-thiazole-5-carboxylic acid; 2-(1-(5-Cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)propan-2-yl)-4-methylthiazole-5-carboxylic acid; 5-Cyclopropyl-3-trifluoromethyl-1H-pyrazole-1-propan-2-yl-4-methyl-1,3-thiazole-5-carboxylic acid; CAS 1006682-82-1; Thiazole-5-carboxylic acid derivative; Pyrazolylpropyl thiazolecarboxylic acid; Advanced heterocyclic building block.
EINECS	Contact for details

Quality Control

Our production of 2-{1-[5-Cyclopropyl-3-(Trifluoromethyl)-1H-Pyrazol-1-Yl]Propan-2-Yl}-4-Methyl-1,3-Thiazole-5-Carboxylic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and compliance with relevant guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.