Description

(7R,8S)-Ethyl 8-Amino-1,4-Dioxaspiro[4.5]Decane-7-Carboxylate is a high-purity, chiral spirocyclic building block of significant interest in advanced organic synthesis. This compound matters as a versatile intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material for its precise stereochemistry, which is critical for creating molecules with specific biological activity and high enantiomeric purity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, including potential antiviral, antibacterial, or central nervous system (CNS) drugs.
• Asymmetric Synthesis: Utilized as a building block in stereoselective reactions to introduce the spirocyclic and amino ester functionalities into target molecules.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization campaigns to explore new chemical space.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and optimization of synthetic routes for complex active pharmaceutical ingredients (APIs).
• Fine Chemical Production: Used in the custom synthesis of specialty chemicals, agrochemicals, and other high-value compounds requiring specific stereochemistry.
• Academic & Industrial Research: A valuable reagent for methodological development in organic chemistry and catalysis research within university and corporate R&D settings.

Basic Information

Product Name	(7R,8S)-Ethyl 8-Amino-1,4-Dioxaspiro[4.5]Decane-7-Carboxylate
CAS No.	1004536-91-7
Molecular Formula	C11H19NO4
Molecular Weight	229.27 g/mol
Synonyms	Ethyl (7R,8S)-8-amino-1,4-dioxaspiro[4.5]decane-7-carboxylate; (7R,8S)-8-Amino-1,4-dioxaspiro[4.5]decane-7-carboxylic acid ethyl ester; 8-Amino-1,4-dioxaspiro[4.5]decane-7-carboxylic acid ethyl ester, (7R,8S)-; (7R,8S)-Ethyl 8-amino-1,4-dioxaspiro[4.5]decane-7-carboxylate; Spirocyclic amino ester; Chiral spiro ketal amino ester
EINECS	Contact for details

Quality Control

Our (7R,8S)-Ethyl 8-Amino-1,4-Dioxaspiro[4.5]Decane-7-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and fine chemical synthesis. Certificates of Analysis (COA) with detailed specifications for identity, purity, and enantiomeric excess are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.