Description

(4S,4'S)-2,2'-Cyclobutylidenebis[4,5-Dihydro-4-(Phenylmethyl)Oxazole] is a chiral bis(oxazoline) ligand, a sophisticated organocatalyst and chiral auxiliary widely utilized in asymmetric synthesis. Its value lies in enabling highly enantioselective transformations, which are critical for producing single-isomer pharmaceutical intermediates and fine chemicals. This product is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• As a chiral ligand in asymmetric catalysis, including Diels-Alder, cyclopropanation, and aldol reactions.
• As a key chiral auxiliary in the synthesis of enantiomerically pure pharmaceutical active ingredients (APIs).
• For the development of novel catalytic systems in academic and industrial research laboratories.
• In the stereoselective synthesis of natural products and complex organic molecules.
• For process optimization and scale-up in fine chemical and custom manufacturing.
• As a building block for constructing more complex, multifunctional ligand frameworks.

Basic Information

Product Name	(4S,4'S)-2,2'-Cyclobutylidenebis[4,5-Dihydro-4-(Phenylmethyl)Oxazole]
CAS No.	1003886-03-0
Molecular Formula	C26H28N2O2
Molecular Weight	400.52 g/mol
Synonyms	(4S,4'S)-2,2'-(Cyclobutane-1,1-diyl)bis(4-benzyl-4,5-dihydrooxazole); (S,S)-Cyclobutane-1,1-diylbis(4-benzyl-4,5-dihydrooxazole); (S,S)-CBDB-Benzyl; Chiral Bis(oxazoline) Ligand; BOX Ligand; (S,S)-Cyclobutyl-BOX; (S,S)-1,1'-Cyclobutylidenebis[4-benzyl-2-oxazoline]; (4S,4'S)-4,4'-Dibenzyl-2,2'-(cyclobutane-1,1-diyl)bis(4,5-dihydrooxazole)
EINECS	Contact for details

Quality Control

Our (4S,4'S)-2,2'-Cyclobutylidenebis[4,5-Dihydro-4-(Phenylmethyl)Oxazole] is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and purity assessment, to ensure it meets the high standards required for asymmetric synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral purity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Specific Rotation	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.