Description

5-Hydroxy-1,1,3,3-Tetramethylisoindoline-2-Oxyl is a stable nitroxide radical derivative, widely recognized as a key building block and spin label in advanced chemical synthesis. Its primary value lies in its persistent radical nature, making it an essential spin trap, polymerization regulator, and paramagnetic probe for electron paramagnetic resonance (EPR) spectroscopy. This compound is critically needed by researchers and manufacturers in the fields of polymer chemistry, materials science, and bioconjugation for developing functional materials and studying molecular dynamics.

Application

• Spin Labeling Agent: Used as a stable radical tag in EPR/ESR spectroscopy for studying protein dynamics, membrane fluidity, and polymer chain mobility.
• Polymerization Regulator: Serves as a controlled radical polymerization agent, such as in Nitroxide-Mediated Polymerization (NMP), for synthesizing polymers with precise architecture.
• Organic Synthesis Intermediate: Acts as a key precursor for synthesizing more complex nitroxide radicals and functionalized isoindoline derivatives.
• Antioxidant Research: Employed as a model compound to study radical scavenging mechanisms and oxidative stress in biochemical systems.
• Materials Science: Incorporated into polymers, coatings, and composites to impart or study paramagnetic properties and enhance material stability.
• Bioconjugation Probe: Used to label biomolecules (e.g., proteins, peptides) for structural and dynamic analysis via magnetic resonance techniques.

Basic Information

Product Name	5-Hydroxy-1,1,3,3-Tetramethylisoindoline-2-Oxyl
CAS No.	1003840-44-5
Molecular Formula	C12H16NO2
Molecular Weight	206.26 g/mol
Synonyms	5-Hydroxy-TEMPO; 5-Hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy (common misnomer based on structure); 5-Hydroxy-1,1,3,3-tetramethylisoindolin-2-yloxyl; 5-Hydroxy-1,1,3,3-tetramethylisoindoline N-oxyl; 5-Hydroxy-1,1,3,3-tetramethyl-2-isoindolinyloxy; 5-Hydroxy-1,1,3,3-tetramethylisoindolin-2-oxyl radical; 5-OH-TMIO; TMIO-OH
EINECS	Contact for details

Quality Control

Our 5-Hydroxy-1,1,3,3-Tetramethylisoindoline-2-Oxyl is produced under strict quality management protocols to ensure batch-to-batch consistency and high radical purity. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles. Our quality systems are designed to support research and development requiring reliable and well-characterized radical precursors.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation. Keep away from strong oxidizing agents and reducing agents.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
EPR Analysis	Characteristic triplet signal
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.