Description

R-(n-Boc)-Piperidine-3-Carboxylhydrazide is a high-purity, protected piperidine derivative that serves as a critical chiral building block in advanced organic synthesis. This compound is essential for the development of novel pharmaceutical candidates, particularly in the creation of complex molecules with specific stereochemistry. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and fine chemical industries for constructing peptidomimetics and other bioactive scaffolds.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Peptidomimetic Research: Used to introduce constrained piperidine motifs into peptide backbones to enhance metabolic stability and bioavailability.
• Agrochemical Development: Building block for creating novel active ingredients with specific stereochemical requirements.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and activity-based probes for target identification and validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and commercial APIs.
• Academic & Institutional Research: Enables methodology development and exploration of new chemical space in medicinal chemistry programs.

Basic Information

Product Name	R-(n-Boc)-Piperidine-3-Carboxylhydrazide
CAS No.	1002359-83-2
Molecular Formula	C11H21N3O3
Molecular Weight	243.30 g/mol
Synonyms	(R)-1-Boc-3-(hydrazinecarbonyl)piperidine; (R)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid hydrazide; (R)-N-Boc-nipecotic acid hydrazide; (R)-1-Boc-3-piperidinecarboxylic acid hydrazide; (3R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]piperidine-3-carbohydrazide; tert-Butyl (3R)-3-(hydrazinecarbonyl)piperidine-1-carboxylate; (R)-Piperidine-3-carboxylic acid, 1-(1,1-dimethylethoxy)carbonyl]-, hydrazide
EINECS	Contact for details

Quality Control

Our R-(n-Boc)-Piperidine-3-Carboxylhydrazide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, chiral HPLC) are provided for every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and prevent decomposition. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.