Description

tert-Butyl 4-(2-Chloropyrimidin-4-yl)piperidine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key building block in modern medicinal chemistry, valued for its role in constructing complex molecular architectures. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas such as oncology and central nervous system disorders.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology Probes: Used in the development of chemical probes to study biological pathways and protein function.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Academic Research: Employed in university and institutional labs for methodological development and exploring new synthetic routes.

Basic Information

Product Name	tert-Butyl 4-(2-Chloropyrimidin-4-yl)piperidine-1-carboxylate
CAS No.	1001754-82-0
Molecular Formula	C14H18ClN3O2
Molecular Weight	295.76 g/mol
Synonyms	1-Boc-4-(2-chloropyrimidin-4-yl)piperidine; 4-(2-Chloro-4-pyrimidinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-(2-chloro-4-pyrimidinyl)-1-piperidinecarboxylate; 1-(tert-Butoxycarbonyl)-4-(2-chloropyrimidin-4-yl)piperidine; 4-(2-Chloropyrimidin-4-yl)piperidine-1-carboxylic acid tert-butyl ester; Boc-4-(2-chloropyrimidin-4-yl)piperidine; 1001754-82-0
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 4-(2-Chloropyrimidin-4-yl)piperidine-1-carboxylate adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.