Description

1-(3,4-Difluorobenzyl)-2-Oxo-1,2-Dihydropyridine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its specific difluorobenzyl and pyridone carboxylic acid structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and target selectivity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in areas such as kinase inhibition and targeted oncology.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel small-molecule drugs.
• Kinase Inhibitor Synthesis: Serves as a core scaffold for constructing potent and selective kinase inhibitors for cancer therapy.
• API Development: Used in the synthetic pathway for advanced Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize drug candidate properties.
• Preclinical Candidate Synthesis: Integral for producing compounds for pharmacological and toxicological evaluation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production.

Basic Information

Product Name	1-(3,4-Difluorobenzyl)-2-Oxo-1,2-Dihydropyridine-3-Carboxylic Acid
CAS No.	1001413-01-9
Molecular Formula	C14H9F2NO3
Molecular Weight	277.22 g/mol
Synonyms	1-[(3,4-Difluorophenyl)methyl]-2-oxo-1,2-dihydro-3-pyridinecarboxylic acid; 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 1,2-dihydro-1-[(3,4-difluorophenyl)methyl]-2-oxo-; 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydro-3-pyridinecarboxylic acid; 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydronicotinic acid
EINECS	Contact for details

Quality Control

Our 1-(3,4-Difluorobenzyl)-2-Oxo-1,2-Dihydropyridine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.