Description

4-Bromo-1-(Pyridine-3-Ylsulfonyl)-1H-Indole CAS NO 1001394-86-0 is a high-purity, advanced heterocyclic building block featuring a brominated indole core functionalized with a pyridylsulfonyl group. This compound is specifically engineered for pharmaceutical research and development, serving as a critical intermediate in the synthesis of novel small molecule therapeutics. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries to create targeted drug candidates, particularly in kinase inhibitor and oncology research programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in oncology and kinase inhibitor research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile reactive sites.
• Chemical Biology: Serves as a probe or precursor for developing enzyme inhibitors and other bioactive molecules.
• Process Research & Development (R&D): Employed in route scouting and scale-up synthesis for active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in universities and research institutes for exploring new heterocyclic chemistry and reaction methodologies.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing specialized compounds for client projects.

Basic Information

Item	Details
Product Name	4-Bromo-1-(Pyridine-3-Ylsulfonyl)-1H-Indole
CAS No.	1001394-86-0
Molecular Formula	C₁₄H₉BrN₂O₂S
Molecular Weight	349.20 g/mol
Synonyms	4-Bromo-1-(pyridin-3-ylsulfonyl)-1H-indole; 1-(Pyridine-3-sulfonyl)-4-bromo-1H-indole; 4-Bromo-1-(3-pyridylsulfonyl)indole; 4-Bromo-1H-indole, 1-[(3-pyridinyl)sulfonyl]-; 1001394-86-0; 4-Bromo-1-(3-pyridinesulfonyl)-1H-indole; 4-Bromo-1-(pyridin-3-ylsulfonyl)indole
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-(Pyridine-3-Ylsulfonyl)-1H-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with the standards expected for pharmaceutical R&D and cGMP starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.