Description

3,3,5,5-Tetrafluoro-Piperidine Hydrochloride is a high-value, fluorinated piperidine derivative used as a key synthetic intermediate in advanced organic chemistry. Its incorporation of fluorine atoms is critical for modulating the physicochemical and metabolic properties of target molecules, making it a sought-after building block. This compound is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the discovery and synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disease research, where fluorine substitution is used to enhance potency and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorinated piperidine core can contribute to improved environmental stability and target specificity.
• Material Science Research: Serves as a precursor for specialty chemicals and advanced materials, including liquid crystals and polymers with unique electronic or surface properties.
• Medicinal Chemistry & SAR Studies: Employed in structure-activity relationship (SAR) studies to investigate the impact of fluorination on biological activity and pharmacokinetic profiles.
• Process Chemistry & Scale-up: Used in route development and optimization for the commercial-scale production of fluorinated active pharmaceutical ingredients (APIs).

Basic Information

Product Name	3,3,5,5-Tetrafluoro-Piperidine Hydrochloride
CAS No.	1001337-97-8
Molecular Formula	C5H8ClF4N
Molecular Weight	193.57 g/mol
Synonyms	3,3,5,5-Tetrafluoropiperidine hydrochloride; Piperidine, 3,3,5,5-tetrafluoro-, hydrochloride; 3,3,5,5-Tetrafluoropiperidine HCl; 3,3,5,5-Tetrafluoro-1-piperidinium chloride; Tetrafluoropiperidine hydrochloride
EINECS	Contact for details

Quality Control

Our 3,3,5,5-Tetrafluoro-Piperidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.