Description

2-Chloro-3-Ethynylquinoline is a high-value, multi-functional heterocyclic building block characterized by its reactive chloro and ethynyl substituents. This compound matters for its versatility in facilitating complex molecular construction, particularly in the synthesis of advanced pharmaceutical intermediates and functional materials. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel compounds with targeted biological or physical properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially kinase inhibitors and other biologically active quinoline derivatives.
• Agrochemical Research: Used in developing novel active ingredients for crop protection products, leveraging its heterocyclic core.
• Material Science: Serves as a monomer or cross-linking agent in the development of advanced polymers, OLED materials, and conductive complexes via Sonogashira and other cross-coupling reactions.
• Chemical Synthesis: An essential building block for palladium-catalyzed cross-coupling reactions (e.g., Sonogashira, Suzuki) to introduce the ethynylquinoline scaffold into more complex architectures.
• Ligand Synthesis: Used in the preparation of novel nitrogen-containing ligands for catalysis and coordination chemistry.

Basic Information

Product Name	2-Chloro-3-Ethynylquinoline
CAS No.	1000782-65-9
Molecular Formula	C11H6ClN
Molecular Weight	187.62 g/mol
Synonyms	3-Ethynyl-2-chloroquinoline; 2-Chloro-3-ethynylquinoline; Quinoline, 2-chloro-3-ethynyl-; 2-Chloroquinoline-3-carbaldehyde (precursor related); 2-Chloro-3-(ethynyl)quinoline
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Ethynylquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.