Description

3-Bromo-5-(Naphthalen-2-Ylsulfonyl)-1,2,4-Thiadiazole is a specialized heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, which combines a reactive bromothiadiazole moiety with a naphthalenesulfonyl group, enabling precise molecular construction. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting enzyme inhibition or protein-protein interactions.
• Agrochemical Research: Used in the development of new herbicides, fungicides, or insecticides, leveraging the bioactivity of the thiadiazole core.
• Material Science: Serves as a building block for creating advanced organic electronic materials, such as charge-transport layers or light-emitting components.
• Chemical Biology Probe: Utilized in the design of molecular probes and inhibitors for studying biological pathways and target validation.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex molecular architectures.
• Sulfonamide Chemistry: The naphthalenesulfonyl group can be exploited in further derivatization to create sulfonamide-based compounds with tailored properties.

Basic Information

Item	Details
Product Name	3-Bromo-5-(Naphthalen-2-Ylsulfonyl)-1,2,4-Thiadiazole
CAS No.	1000575-53-0
Molecular Formula	C₁₂H₇BrN₂O₂S₂
Molecular Weight	355.23 g/mol
Synonyms	3-Bromo-5-(naphthalene-2-sulfonyl)-1,2,4-thiadiazole; 2-(5-Bromo-1,2,4-thiadiazol-3-ylsulfonyl)naphthalene; 1,2,4-Thiadiazole, 3-bromo-5-[(2-naphthalenyl)sulfonyl]-; 3-Bromo-5-(2-naphthylsulfonyl)-1,2,4-thiadiazole; 1000575-53-0; 3-Br-5-Ns-1,2,4-thiadiazole
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) detailing all critical parameters are available upon request, providing full traceability and supporting your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). This compound may be sensitive to moisture and should be handled under inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.