Description

Inosine,1-Phenyl-2",3",5-Tris-O(Tetrahydro-2H-Pyran-2-Yl)-(9Ci) is a key protected nucleoside derivative, specifically a modified inosine where the ribose hydroxyl groups are shielded by tetrahydro-2H-pyran-2-yl (THP) protecting groups. This chemical structure is critical for enabling selective reactions in complex organic syntheses, particularly in the development of novel pharmaceutical compounds and advanced nucleotide analogs. It serves as a vital high-purity building block for researchers and manufacturers in medicinal chemistry, requiring precise control over molecular architecture.

Application

• Pharmaceutical Intermediate: Serves as a protected precursor in the multi-step synthesis of antiviral and anticancer nucleoside analogs.
• Medicinal Chemistry Research: Used in the discovery and development of new therapeutic agents targeting viral polymerases and other nucleotide-binding proteins.
• Oligonucleotide Synthesis: Acts as a specialized monomer for constructing modified RNA or DNA strands with enhanced stability or specific binding properties.
• Bioconjugation & Probe Development: Utilized in creating labeled nucleotides for diagnostic assays and biochemical research tools.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) in GMP environments.

Basic Information

Product Name	Inosine,1-Phenyl-2",3",5-Tris-O(Tetrahydro-2H-Pyran-2-Yl)-(9Ci)
CAS No.	199988-53-9
Molecular Formula	C₂₆H₃₄N₄O₈
Molecular Weight	530.57 g/mol
Synonyms	1-Phenyl-2',3',5'-tris-O-(tetrahydro-2H-pyran-2-yl)inosine; 9H-Purin-6-ol, 9-(1-phenyl-2,3,5-tris-O-(tetrahydro-2H-pyran-2-yl)-β-D-ribofuranosyl)-; 1-Phenyl-2',3',5'-tri-O-(tetrahydro-2-pyranyl)inosine; THP-Protected Phenylinosine; Inosine derivative, THP-protected; 1-Phenylinosine 2',3',5'-tris(tetrahydropyranyl) ether
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high chemical purity, essential for sensitive synthetic applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. We support custom synthesis and can tailor specifications to meet specific research or cGMP development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed in a dry environment to prevent moisture uptake, which can compromise stability and reactivity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.