Description

Spiro[Cyclopropane-1,3-[3H]Pyrrolo[2,3-B]Pyridine] (9Ci) is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic-fused heterocyclic structure. This compound is of significant value for medicinal chemistry research and development, offering a sophisticated scaffold for constructing novel bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors to explore new therapeutic pathways and develop innovative active pharmaceutical ingredients (APIs).

Application

This specialized spirocyclic intermediate serves as a critical building block in advanced organic synthesis. Its primary applications include:

• Pharmaceutical R&D: As a key precursor for synthesizing novel drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry: Used to introduce conformational constraint and explore structure-activity relationships (SAR) in lead optimization programs.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and development of robust synthetic routes for potential APIs.
• Chemical Biology: Employed in the design and synthesis of molecular probes for studying biological targets and pathways.
• Academic Research: Utilized in university and institutional labs for methodological development in heterocyclic and spirocyclic chemistry.

Basic Information

Product Name	Spiro[Cyclopropane-1,3-[3H]Pyrrolo[2,3-B]Pyridine] (9Ci)
CAS No.	199011-09-1
Molecular Formula	C9H8N2
Molecular Weight	144.18 g/mol
Synonyms	Spiro[cyclopropane-1,3'-[3H]pyrrolo[2,3-b]pyridine]; 1'H-Spiro[cyclopropane-1,3'-pyrrolo[2,3-b]pyridine]; 1'H-Spiro(cyclopropane-1,3'-pyrrolo[2,3-b]pyridine); Spiro(cyclopropane-1,3'-[3H]pyrrolo[2,3-b]pyridine); 199011-09-1; Spiro-cyclopropane-pyrrolopyridine; 3'H-Spiro[cyclopropane-1,1'-pyrrolo[2,3-b]pyridine]
EINECS	Contact for details

Quality Control

Our Spiro[Cyclopropane-1,3-[3H]Pyrrolo[2,3-B]Pyridine] (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data, including HPLC purity, NMR, and MS confirmation. Our quality commitment aligns with the standards expected for pharmaceutical R&D and process development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.