Description

1-Boc-4-Cyano-4-(3-Methylphenyl)-Piperidine is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine core functionalized with cyano and tert-butoxycarbonyl (Boc) protecting groups. This compound is a critical building block in modern organic synthesis, enabling the efficient construction of complex molecules with precise stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly within central nervous system (CNS) and oncology therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates, especially those targeting neurological receptors.
• Chemical Synthesis Building Block: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization due to its versatile reactive sites.
• Protease Inhibitor Research: Acts as a core scaffold in the development of protease inhibitors and other enzyme-targeted therapies.
• Ligand Synthesis: Employed in the creation of specialized ligands for pharmacological and biochemical assays.
• Custom Synthesis Projects: A valuable starting material for contract research organizations (CROs) and CDMOs working on custom synthetic routes.
• Academic Research: Utilized in university and institutional labs for methodological development in heterocyclic and organonitrogen chemistry.

Basic Information

Product Name	1-Boc-4-Cyano-4-(3-Methylphenyl)-Piperidine
CAS No.	198649-43-3
Molecular Formula	C18H24N2O2
Molecular Weight	300.40 g/mol
Synonyms	1-Boc-4-cyano-4-(m-tolyl)piperidine; tert-Butyl 4-cyano-4-(3-methylphenyl)piperidine-1-carboxylate; 4-Cyano-4-(3-methylphenyl)piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-cyano-4-(3-methylphenyl)piperidine; 4-(3-Methylphenyl)-4-cyanopiperidine-1-carboxylic acid tert-butyl ester; BOC-4-Cyano-4-(3-Methylphenyl)Piperidine
EINECS	Contact for details

Quality Control

Our 1-Boc-4-Cyano-4-(3-Methylphenyl)-Piperidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material is suitable for use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.