Description

7-[(5R,6S)-6-Hydroxy-2,2-Dimethyl-1,3-Dioxepan-5-Yl]-1,4,7,10-Tetraazacyclododecane-1-Carboxaldehyde is a sophisticated macrocyclic ligand precursor, a key building block in the synthesis of advanced chelating agents. Its value lies in its precise stereochemistry and functional groups, which enable the creation of highly stable and selective metal complexes. This compound is essential for researchers and manufacturers in the pharmaceutical, diagnostic imaging, and catalysis sectors, particularly for developing novel radiopharmaceuticals and contrast agents.

Application

• Radiopharmaceutical Precursor: A critical intermediate in the synthesis of bifunctional chelators for labeling antibodies, peptides, and small molecules with diagnostic (e.g., 68Ga, 64Cu) and therapeutic (e.g., 177Lu, 225Ac) radioisotopes.
• MRI Contrast Agent Development: Used to create gadolinium(III) or other lanthanide-based complexes for magnetic resonance imaging (MRI) enhancement.
• Catalysis Research: Serves as a ligand scaffold for designing homogeneous catalysts in asymmetric synthesis and other specialized chemical transformations.
• Chemical Biology Probes: Enables the construction of metal-chelating tags for studying protein function, localization, and interactions within biological systems.
• Advanced Material Synthesis: A building block for functionalized polymers, sensors, and separation materials that require specific metal-binding sites.

Basic Information

Product Name	7-[(5R,6S)-6-Hydroxy-2,2-Dimethyl-1,3-Dioxepan-5-Yl]-1,4,7,10-Tetraazacyclododecane-1-Carboxaldehyde
CAS No.	198637-59-1
Molecular Formula	C16H29N5O4
Molecular Weight	355.44 g/mol
Synonyms	DO3A-CHO aldehyde; (5R,6S)-5-(4,7,10-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl)methyl-6-hydroxy-2,2-dimethyl-1,3-dioxepane; 1,4,7,10-Tetraazacyclododecane-1-acetaldehyde, 7-[(5R,6S)-6-hydroxy-2,2-dimethyl-1,3-dioxepan-5-yl]-; DO3A-tris(t-butyl ester) monoaldehyde; Cyclen-based bifunctional chelator precursor; 1-Carboxaldehyde-DO3A
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for sensitive synthetic applications. Identity and purity are verified by a suite of analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) for long-term stability, as this compound is hygroscopic (moisture-sensitive) and easily oxidized. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.