Description

Fmoc-L-Indoline-2-Carboxylic Acid CAS NO 198560-38-2 is a high-purity, protected amino acid derivative essential for modern solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for introducing the unique, constrained indoline scaffold into peptide chains, enabling the development of novel bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, medicinal chemistry, and the synthesis of peptide-based therapeutics and diagnostics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated or manual construction of complex peptides.
• Medicinal Chemistry & Drug Discovery: Used to incorporate the rigid, bicyclic indoline structure into lead compounds to modulate conformation, bioavailability, and receptor binding affinity.
• Peptidomimetic Design: Essential for creating non-natural peptide analogs with enhanced metabolic stability and pharmacological properties.
• Chemical Biology Probes: Synthesis of labeled or tagged peptides for studying protein-protein interactions and enzyme mechanisms.
• Pharmaceutical Intermediate: Serves as a precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) targeting various diseases.
• Academic & Industrial R&D: Fundamental reagent for research in organic synthesis, peptide science, and new material development.

Basic Information

Product Name	Fmoc-L-Indoline-2-Carboxylic Acid
CAS No.	198560-38-2
Molecular Formula	C24H19NO4
Molecular Weight	385.41 g/mol
Synonyms	(2S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2,3-dihydro-1H-indole-2-carboxylic acid; Fmoc-L-2-Indolinecarboxylic Acid; Fmoc-Indoline-2-COOH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-indoline-2-carboxylic acid; N-α-Fmoc-L-indoline-2-carboxylic acid; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2,3-dihydro-1H-indole-2-carboxylic acid; Fmoc-L-Indo(2)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-L-Indoline-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and chiral integrity. Certificates of Analysis (COA) with detailed specifications are provided for each lot, supporting compliance with research and cGMP guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.