Description

Boc-3,4-Difluoro-L-Phe-Oh Dcha is a protected, fluorinated derivative of the essential amino acid L-phenylalanine, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in enabling the precise introduction of a difluorinated aromatic moiety into peptide chains and other complex molecules, which is essential for modulating their biological activity, metabolic stability, and physicochemical properties. This high-purity intermediate is indispensable for researchers and manufacturers in the pharmaceutical industry, particularly in the development of novel active pharmaceutical ingredients (APIs), peptide-based therapeutics, and agrochemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and production of fluorinated peptide drugs and protease inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate fluorinated phenylalanine residues, enhancing peptide stability and lipophilicity.
• Medicinal Chemistry Research: A vital building block for structure-activity relationship (SAR) studies to explore the effects of fluorine substitution on drug potency and pharmacokinetics.
• Agrochemical Development: Intermediate in the synthesis of advanced, fluorinated herbicides and pesticides where the difluoro group can improve efficacy and environmental profile.
• Bioconjugation & Probe Development: Useful for creating fluorinated probes and labeled biomolecules for imaging and diagnostic applications.

Basic Information

Product Name	Boc-3,4-Difluoro-L-Phe-Oh Dcha
CAS No.	198474-91-8
Molecular Formula	C₂₀H₂₈F₂N₂O₄ • C₁₄H₂₃N
Molecular Weight	~ 585.67 g/mol (Free acid: 342.35 g/mol)
Synonyms	N-α-(tert-Butoxycarbonyl)-3,4-difluoro-L-phenylalanine dicyclohexylamine salt; Boc-3,4-Difluoro-L-phenylalanine DCHA salt; (2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-(3,4-difluorophenyl)propanoic acid - bis(cyclohexyl)amine (1:1); N-Boc-3,4-difluoro-L-phenylalanine DCHA salt; Boc-DifluoroPhe-OH•DCHA; BOC-L-3,4-Difluorophenylalanine Dicyclohexylamine Salt; tert-Butoxycarbonyl-3,4-difluoro-L-phenylalanine dicyclohexylammonium salt.
EINECS	Contact for details

Quality Control

Our Boc-3,4-Difluoro-L-Phe-Oh Dcha is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP applications. Each lot undergoes comprehensive analytical testing, including chiral purity verification and stringent control of organic impurities. A detailed Certificate of Analysis (COA) documenting identity, purity (HPLC), specific rotation, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Specific Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.