Description

1-(5-Chloro-2-Methylphenyl)-3-(2,4-Difluorophenyl)Urea is a high-purity, diaryl urea derivative of significant interest in advanced chemical synthesis. This compound serves as a critical building block for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique halogenated aromatic structure imparts specific biological activity and binding properties. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical and agrochemical sectors for lead optimization and process development.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of kinase inhibitors and other small-molecule therapeutic candidates.
• Agrochemical Research: Used as a core scaffold for developing new herbicides and fungicides with enhanced efficacy.
• Chemical Biology: Serves as a probe or ligand in biochemical assays to study protein-ligand interactions.
• Material Science: Potential monomer or additive in the synthesis of specialized polymers with unique properties.
• Contract Research & Development (CRO/CMO): Supplied to organizations engaged in custom synthesis and scale-up projects.

Basic Information

Product Name	1-(5-Chloro-2-Methylphenyl)-3-(2,4-Difluorophenyl)Urea
CAS No.	196879-47-7
Molecular Formula	C14H11ClF2N2O
Molecular Weight	296.70 g/mol
Synonyms	N-(5-Chloro-2-methylphenyl)-N'-(2,4-difluorophenyl)urea; 1-(5-Chloro-o-tolyl)-3-(2,4-difluorophenyl)urea; Urea, N-(5-chloro-2-methylphenyl)-N'-(2,4-difluorophenyl)-; (5-Chloro-2-methylphenyl)-(2,4-difluorophenyl)urea; BAY 43-9006 Impurity; Sorafenib Impurity; Diaryluerea Derivative
EINECS	Contact for details

Quality Control

Our 1-(5-Chloro-2-Methylphenyl)-3-(2,4-Difluorophenyl)Urea is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.