Description

4-(4-Bromo-2-Fluoroanilino)-7-Hydroxy-6-Methoxyquinazoline is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery and development. This compound serves as a critical building block in the synthesis of targeted kinase inhibitors, offering researchers a reliable and well-characterized starting material. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the development of novel anticancer and therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel tyrosine kinase inhibitor (TKI) candidates for oncology research.
• Anticancer Drug Development: Used in the research and development of targeted therapies that interfere with specific signaling pathways in cancer cells.
• Biochemical Research: Serves as a reference standard and a tool compound for studying enzyme inhibition and structure-activity relationships (SAR).
• API Synthesis: Employed in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) for preclinical and clinical studies.
• Fine Chemical Manufacturing: Utilized in the production of complex, high-value specialty chemicals for the life sciences sector.

Basic Information

Product Name	4-(4-Bromo-2-Fluoroanilino)-7-Hydroxy-6-Methoxyquinazoline
CAS No.	196603-96-0
Molecular Formula	C₁₅H₁₁BrFN₃O₂
Molecular Weight	364.17 g/mol
Synonyms	4-[(4-Bromo-2-fluorophenyl)amino]-7-hydroxy-6-methoxyquinazoline; 7-Hydroxy-6-methoxy-4-[(4-bromo-2-fluorophenyl)amino]quinazoline; BIBF 1120 Intermediate; Nintedanib Impurity; Nintedanib Related Compound; Vargatef Intermediate; 4-(4-Bromo-2-fluoroanilino)-7-hydroxy-6-methoxyquinazoline; 196603-96-0
EINECS	Contact for details

Quality Control

Our 4-(4-Bromo-2-Fluoroanilino)-7-Hydroxy-6-Methoxyquinazoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to protect the integrity of the material.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.