Description

2-Chloro-6,7-Difluorobenzoxazole is a high-purity fluorinated heterocyclic building block of significant importance in advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecules, particularly in the development of pharmaceuticals and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing benzoxazole and difluorophenyl motifs for targeted therapies.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoro and chloro substituents enhance biological activity and stability.
• Material Science Research: Serves as a building block for novel organic electronic materials, ligands for catalysts, and advanced polymers.
• Cross-Coupling Reactions: The chloro substituent makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to form carbon-carbon and carbon-heteroatom bonds.
• Fluorine Chemistry: An essential reagent for introducing fluorine atoms into complex molecular architectures to modulate lipophilicity, metabolic stability, and binding affinity.

Basic Information

Product Name	2-Chloro-6,7-Difluorobenzoxazole
CAS No.	195737-22-5
Molecular Formula	C7H2ClF2NO
Molecular Weight	189.55 g/mol
Synonyms	2-Chloro-6,7-difluoro-1,3-benzoxazole; 6,7-Difluoro-2-chlorobenzoxazole; Benzoxazole, 2-chloro-6,7-difluoro-; 195737-22-5; 2-Chloro-6,7-difluorobenzo[d]oxazole
EINECS	Contact for details

Quality Control

Our 2-Chloro-6,7-Difluorobenzoxazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and fluorides. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.